DNA looping in gene regulation: from the assembly of macromolecular complexes to the control of transcriptional noise
arXiv:q-bio/0502044 · doi:10.1016/j.gde.2005.02.005
Abstract
The formation of DNA loops by proteins and protein complexes that bind at distal DNA sites plays a central role in many cellular processes, such as transcription, recombination, and replication. Here we review the basic thermodynamic concepts underlying the assembly of macromolecular complexes on looped DNA and the effects that this process has in the properties of gene regulation. Beyond the traditional view of DNA looping as a mechanism to increase the affinity of regulatory molecules for their cognate sites, recent developments indicate that DNA looping can also lead to the suppression of cell-to-cell variability, the control of transcriptional noise, and the activation of cooperative interactions on demand.
To appear in Current Opinion in Genetics & Development
Cited by in corpus (13)
- Quantitative Characterization of Combinatorial Transcriptional Control of the Lactose Operon of E. coli
- DNA looping: the consequences and its control
- Stochastic dynamics of macromolecular-assembly networks
- Depletion effects and loop formation in self-avoiding polymers
- Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation
- Multilevel Deconstruction of the In Vivo Behavior of Looped DNA-Protein Complexes
- Multiprotein DNA looping
- Control of gene expression by modulated self-assembly
- Unifying thermodynamic and kinetic descriptions of single-molecule processes: RNA unfolding under tension
- A thermodynamic model for agglomeration of DNA-looping proteins
- In vivo evidence of alternative loop geometries in DNA-protein complexes
- Efficiency and versatility of distal multisite transcription regulation
- Figure 1 Theory Meets Figure 2 Experiments in the Study of Gene Expression