302 citations · 2.5k across the 74 of their papers we have counts for
7 papers · 1 filter
A topological look into the evolution of developmental programs
Somya Mani, Tsvi Tlusty
Rapid advance of experimental techniques provides an unprecedented in-depth view into complex developmental processes. Still, little is known on how the complexity of multicellular…
Large-Scale Survey of Cell-Differentiation Programs in a Generative Model Reveals Regeneration as an Epiphenomenon of Development
Somya Mani, Tsvi Tlusty
Development combines three basic processes asymmetric --- cell division, signaling and gene regulation --- in a multitude of ways to create an overwhelming diversity of multicellul…
Evolution of bow-tie architectures in biology
Tamar Friedlander, Avraham E. Mayo, Tsvi Tlusty +1
Bow-tie or hourglass structure is a common architectural feature found in biological and technological networks. A bow-tie in a multi-layered structure occurs when intermediate lay…
Mutation Rules and the Evolution of Sparseness and Modularity in Biological Systems
Tamar Friedlander, Avraham E. Mayo, Tsvi Tlusty +1
Biological systems exhibit two structural features on many levels of organization: sparseness, in which only a small fraction of possible interactions between components actually o…
A Coarse-Grained Biophysical Model of E. coli and Its Application to Perturbation of the rRNA Operon Copy Number
Arbel D. Tadmor, Tsvi Tlusty
We propose a biophysical model of Escherichia coli that predicts growth rate and an effective cellular composition from an effective, coarse-grained representation of its genome. W…
Optimal Design of a Molecular Recognizer: Molecular Recognition as a Bayesian Signal Detection Problem
Yonatan Savir, Tsvi Tlusty
Numerous biological functions-such as enzymatic catalysis, the immune response system, and the DNA-protein regulatory network-rely on the ability of molecules to specifically recog…