179 citations · 635 across the 21 of their papers we have counts for
7 papers · 1 filter
Adaptive mechanical proofreading toward faithful clonal selection
Qing Xu, Shenshen Wang
To ensure faithful information transmission, cells utilize nonequilibrium drives to reduce errors. Kinetic proofreading is a classic mechanism known to sharpen ligand discriminatio…
Molecular tug of war reveals adaptive potential of an immune cell repertoire
Hongda Jiang, Shenshen Wang
The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relie…
Trait-space patterning and the role of feedback in antigen-immunity coevolution
Hongda Jiang, Shenshen Wang
Coevolutionary arms races form between interacting populations that constitute each other's environment and respond to mutual changes. This inherently far-from-equilibrium process…
Evolving generalists via dynamic sculpting of rugged landscapes
Shenshen Wang, Lei Dai
Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a microbial population exposed to varied antibiotics, constantly search for adaptive solutions i…
Active tuning of synaptic patterns enhances immune discrimination
Miloš Knežević, Shenshen Wang
Immune cells learn about their antigenic targets using tactile sense: during recognition, a highly organized yet dynamic motif, named immunological synapse, forms between immune ce…
Tensegrity and Motor-Driven Effective Interactions in a Model Cytoskeleton
Shenshen Wang, Peter G. Wolynes
Actomyosin networks are major structural components of the cell. They provide mechanical integrity and allow dynamic remodeling of eukaryotic cells, self-organizing into the divers…