37 citations · 75 across the 30 of their papers we have counts for
3 papers · 1 filter
Design of platform trials with a change in the control treatment arm
Peter Greenstreet, Thomas Jaki, Alun Bedding +1
Platform trials are a more efficient way of testing multiple treatments compared to running separate trials. In this paper we consider platform trials where, if a treatment is foun…
A preplanned multi-stage platform trial for discovering multiple superior treatments with control of FWER and power
Peter Greenstreet, Thomas Jaki, Alun Bedding +1
There is a growing interest in the implementation of platform trials, which provide the flexibility to incorporate new treatment arms during the trial and the ability to halt treat…
Adaptive enrichment trial designs using joint modeling of longitudinal and time-to-event data
Abigail J. Burdon, Richard D. Baird, Thomas Jaki
Adaptive enrichment allows for pre-defined patient subgroups of interest to be investigated throughout the course of a clinical trial. Many trials which measure a long-term time-to…