165 citations · 243 across the 12 of their papers we have counts for
3 papers · 1 filter
Generating the right evidence at the right time: Principles of a new class of flexible augmented clinical trial designs
Cornelia Dunger-Baldauf, Rob Hemmings, Frank Bretz +3
The past few years have seen an increasing number of initiatives aimed at integrating information generated outside of confirmatory randomised clinical trials (RCTs) into drug deve…
Confidence Sets for a level set in linear regression
Fang Wan, Wei Liu, Frank Bretz
Regression modeling is the workhorse of statistics and there is a vast literature on estimation of the regression function. It is realized in recent years that in regression analys…
Estimands and their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic: A Report from the NISS Ingram Olkin Forum Series on Unplanned Clinical Trial Disruptions
Kelly Van Lancker, Sergey Tarima, Jonathan Bartlett +8
The COVID-19 pandemic continues to affect the conduct of clinical trials globally. Complications may arise from pandemic-related operational challenges such as site closures, trave…