165 citations · 243 across the 12 of their papers we have counts for
3 papers · 1 filter
Assessing the similarity of dose response and target doses in two non-overlapping subgroups
Frank Bretz, Kathrin Möllenhoff, Holger Dette +2
We consider two problems that are attracting increasing attention in clinical dose finding studies. First, we assess the similarity of two non-linear regression models for two non-…
On weighted parametric tests
Dong Xi, Ekkehard Glimm, Willi Maurer +1
We describe a general framework for weighted parametric multiple test procedures based on the closure principle. We utilize general weighting strategies that can reflect complex st…
Optimal designs for active controlled dose finding trials with efficacy-toxicity outcomes
Holger Dette, Katrin Kettelhake, Kirsten Schorning +2
Nonlinear regression models addressing both efficacy and toxicity outcomes are increasingly used in dose-finding trials, such as in pharmaceutical drug development. However, resear…