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stat.ME2022
A Bayesian design for dual-agent dose optimization with targeted therapies
José L. Jiménez, Mourad Tighiouart
In this article, we propose a phase I-II design in two stages for the combination of molecularly targeted therapies. The design is motivated by a published case study that combines…
stat.ME2022
Modeling synergism in early phase cancer trials with drug combination with continuous dose levels: is there an added value?
Mourad Tighiouart, José L. Jiménez, Marcio A. Diniz +1
In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there…