1 citations · 1 across the 4 of their papers we have counts for
4 papers
Visualizing hypothesis tests in survival analysis under anticipated delayed effects
José L. Jiménez, Isobel Barrott, Francesca Gasperoni +1
What can be considered an appropriate statistical method for the primary analysis of a randomized clinical trial (RCT) with a time-to-event endpoint when we anticipate non-proporti…
A Bayesian design for dual-agent dose optimization with targeted therapies
José L. Jiménez, Mourad Tighiouart
In this article, we propose a phase I-II design in two stages for the combination of molecularly targeted therapies. The design is motivated by a published case study that combines…
Modeling synergism in early phase cancer trials with drug combination with continuous dose levels: is there an added value?
Mourad Tighiouart, José L. Jiménez, Marcio A. Diniz +1
In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there…
A Bayesian adaptive design for dual-agent phase I-II oncology trials integrating efficacy data across stages
José L. Jiménez, Haiyan Zheng
Combination of several anti-cancer treatments has typically been presumed to have enhanced drug activity. Motivated by a real clinical trial, this paper considers phase I-II dose f…