76 citations · 161 across the 17 of their papers we have counts for
6 papers · 1 filter
Topological Data Analysis of Single-cell Hi-C Contact Maps
Mathieu Carriere, Raul Rabadan
In this article, we show how the recent statistical techniques developed in Topological Data Analysis for the Mapper algorithm can be extended and leveraged to formally define and…
Dose-response modeling in high-throughput cancer drug screenings: An end-to-end approach
Wesley Tansey, Kathy Li, Haoran Zhang +4
Personalized cancer treatments based on the molecular profile of a patient's tumor are an emerging and exciting class of treatments in oncology. As genomic tumor profiling is becom…
The Holdout Randomization Test for Feature Selection in Black Box Models
Wesley Tansey, Victor Veitch, Haoran Zhang +2
We propose the holdout randomization test (HRT), an approach to feature selection using black box predictive models. The HRT is a specialized version of the conditional randomizati…
Quasi-universality in single-cell sequencing data
Luis Aparicio, Mykola Bordyuh, Andrew J. Blumberg +1
The development of single-cell technologies provides the opportunity to identify new cellular states and reconstruct novel cell-to-cell relationships. Applications range from under…
Black Box FDR
Wesley Tansey, Yixin Wang, David M. Blei +1
Analyzing large-scale, multi-experiment studies requires scientists to test each experimental outcome for statistical significance and then assess the results as a whole. We presen…
Quantifying Genetic Innovation: Mathematical Foundations for the Topological Study of Reticulate Evolution
Michael Lesnick, Raúl Rabadán, Daniel I. S. Rosenbloom
A topological approach to the study of genetic recombination, based on persistent homology, was introduced by Chan, Carlsson, and Rabadán in 2013. This associates a sequence of sig…