36 citations · 57 across the 10 of their papers we have counts for
11 papers
Incorporating Individual and Collective Ethics into Phase I Cancer Trial Designs
Jay Bartroff, Tze Leung Lai
A general framework is proposed for Bayesian model-based designs of Phase I cancer trials, in which a general criterion for coherence (Cheung, 2005) of a design is also developed.…
The Fighter Problem: Optimal Allocation of a Discrete Commodity
Jay Bartroff, Ester Samuel-Cahn
The Fighter problem with discrete ammunition is studied. An aircraft (fighter) equipped with anti-aircraft missiles is intercepted by enemy airplanes, the appearance of which f…
Multistage tests of multiple hypotheses
Jay Bartroff, Tze Leung Lai
Conventional multiple hypothesis tests use step-up, step-down, or closed testing methods to control the overall error rates. We will discuss marrying these methods with adaptive mu…
Generalized Likelihood Ratio Statistics and Uncertainty Adjustments in Efficient Adaptive Design of Clinical Trials
Jay Bartroff, Tze Leung Lai
A new approach to adaptive design of clinical trials is proposed in a general multiparameter exponential family setting, based on generalized likelihood ratio statistics and optima…
Efficient adaptive designs with mid-course sample size adjustment in clinical trials
Jay Bartroff, Tze Leung Lai
Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Where…
Optimal Multistage Sampling in a Boundary-Crossing Problem
Jay Bartroff
Brownian motion with known positive drift is sampled in stages until it crosses a positive boundary . A family of multistage samplers that control the expected overshoot over th…