36 citations · 57 across the 10 of their papers we have counts for
4 papers · 1 filter
Incorporating Individual and Collective Ethics into Phase I Cancer Trial Designs
Jay Bartroff, Tze Leung Lai
A general framework is proposed for Bayesian model-based designs of Phase I cancer trials, in which a general criterion for coherence (Cheung, 2005) of a design is also developed.…
Multistage tests of multiple hypotheses
Jay Bartroff, Tze Leung Lai
Conventional multiple hypothesis tests use step-up, step-down, or closed testing methods to control the overall error rates. We will discuss marrying these methods with adaptive mu…
Efficient adaptive designs with mid-course sample size adjustment in clinical trials
Jay Bartroff, Tze Leung Lai
Adaptive designs have been proposed for clinical trials in which the nuisance parameters or alternative of interest are unknown or likely to be misspecified before the trial. Where…
Approximate Dynamic Programming and Its Applications to the Design of Phase I Cancer Trials
Jay Bartroff, Tze Leung Lai
Optimal design of a Phase I cancer trial can be formulated as a stochastic optimization problem. By making use of recent advances in approximate dynamic programming to tackle the p…