365 citations · 2k across the 65 of their papers we have counts for
8 papers · 1 filter
Optimal discrete control: minimizing dissipation in discretely driven nonequilibrium systems
Steven J. Large, David A. Sivak
Microscopic machines utilize free energy to create and maintain out-of-equilibrium organization in virtually all living things. Often this takes the form of converting the free ene…
Breaking time-reversal symmetry for ratchet models of molecular machines
Arshia Zarrin, David A. Sivak, Aidan I. Brown
Biomolecular machines transduce free energy from one form to another to fulfill many important roles inside cells, with dissipation required to achieve directed progress. We invest…
Optimal control of protein copy number
Steven Blaber, David A. Sivak
Cell-cell communication is often achieved by secreted signaling molecules that bind membrane-bound receptors. A common class of such receptors are G-protein coupled receptors, wher…
Optimal Control of Rotary Motors
Joseph N. E. Lucero, Aliakbar Mehdizadeh, David A. Sivak
Single-molecule experiments have found near-perfect thermodynamic efficiency in the rotary motor F1-ATP synthase. To help elucidate the principles underlying nonequilibrium energet…
Energy dissipation and information flow in coupled Markovian systems
Matthew E. Quenneville, David A. Sivak
A stochastic system under the influence of a stochastic environment is correlated with both present and future states of the environment. Such a system can be seen as implicitly im…
Pulling cargo increases the precision of molecular motor progress
Aidan I Brown, David A Sivak
Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-…