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q-bio.MN2024
Multi-Scale Hybrid Modeling to Predict Cell Culture Process with Metabolic Phase Transitions
Keqi Wang, Sarah W. Harcum, Wei Xie
To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework desig…
q-bio.MN2023★ 1 cited
Stochastic Biological System-of-Systems Modelling for iPSC Culture
Hua Zheng, Sarah W. Harcum, Jinxiang Pei +1
Large-scale manufacturing of induced pluripotent stem cells (iPSCs) is essential for cell therapies and regenerative medicines. Yet, iPSCs form large cell aggregates in suspension…
q-bio.MN2023★ 1 cited
Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs
Keqi Wang, Wei Xie, Sarah W. Harcum
The rapidly expanding market for regenerative medicines and cell therapies highlights the need to advance the understanding of cellular metabolisms and improve the prediction of cu…