1 citations · 2 across the 5 of their papers we have counts for
5 papers
GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei +1
Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a s…
Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing
Fuqiang Cheng, Zahra Foroozan Jahromi, Keqi Wang +10
Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D ag…
Multi-Scale Hybrid Modeling to Predict Cell Culture Process with Metabolic Phase Transitions
Keqi Wang, Sarah W. Harcum, Wei Xie
To advance understanding of cellular metabolism and reduce batch-to-batch variability in cell culture processes, this study introduces a multi-scale hybrid modeling framework desig…
Stochastic Biological System-of-Systems Modelling for iPSC Culture
Hua Zheng, Sarah W. Harcum, Jinxiang Pei +1
Large-scale manufacturing of induced pluripotent stem cells (iPSCs) is essential for cell therapies and regenerative medicines. Yet, iPSCs form large cell aggregates in suspension…
Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs
Keqi Wang, Wei Xie, Sarah W. Harcum
The rapidly expanding market for regenerative medicines and cell therapies highlights the need to advance the understanding of cellular metabolisms and improve the prediction of cu…