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q-bio.CB2026
GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
Yuming Zeng, Sarah W. Harcum, Jinxiang Pei +1
Antibody productivity and glycosylation quality in CHO cell cultures emerge from a dynamically evolving metabolic environment, yet existing models often work in isolation or at a s…
q-bio.CB2026
Intracellular Measurement-Informed Multiscale Modeling for Scalable iPSC Manufacturing
Fuqiang Cheng, Zahra Foroozan Jahromi, Keqi Wang +10
Scalable manufacturing of human induced pluripotent stem cells (iPSCs) is essential for industrial-scale production of cell therapies and regenerative medicines. However, the 3D ag…