activity
20242026
most citedQuasi-Steady-State Approach for Efficient Multiscale Simulation and Optimization of mAb Glycosylation in CHO Cell Culture

6 citations · 10 across the 10 of their papers we have counts for

collaborators

11 papers

eess.SY2026

A Koopman--Polynomial Chaos Framework for SMPC of Nonlinear Stochastic Processes

Wallace Gian Yion Tan, Efstathios Iliakis, Liang Wu +2

This paper develops a polynomial parametric Koopman operator (PPKO) framework for stochastic model predictive control (SMPC) of nonlinear systems with parametric uncertainty and ti…

eess.SY2026

Physics-Informed Neural Network Surrogates with Polynomial Chaos-Based Uncertainty Propagation for Stochastic Model Predictive Control

Srimanta Santra, Romi Patel, Saikat Mukherjee +2

Stochastic partial differential equations (PDEs) govern critical engineering and geophysical systems but are challenging to use for real-time control under parametric uncertainty.…

cs.LG2026

Improving Performance in Classification Tasks with LCEN and the Weighted Focal Differentiable MCC Loss

Pedro Seber, Richard D. Braatz

The LASSO-Clip-EN (LCEN) algorithm was previously introduced for nonlinear, interpretable feature selection and machine learning. However, its design and use was limited to regress…

math.OC2026

Fixed-time-stable ODE Representation of Lasso

Liang Wu, Yunhong Che, Wallace Gian Yion Tan +3

Lasso problems arise in many areas, including signal processing, machine learning, and control, and are closely connected to sparse coding mechanisms observed in neuroscience. A co…

eess.SY2026

Polynomial Parametric Koopman Operators for Stochastic MPC

Efstathios Iliakis, Wallace Gian Yion Tan, Liang Wu +2

This paper develops a parametric Koopman operator framework for Stochastic Model Predictive Control (SMPC), where the Koopman operator is parametrized by Polynomial Chaos Expansion…

eess.SY2026

LQR for Systems with Probabilistic Parametric Uncertainties: A Gradient Method

Leilei Cui, Richard D. Braatz

A gradient-based method is proposed for solving the linear quadratic regulator (LQR) problem for linear systems with nonlinear dependence on time-invariant probabilistic parametric…

eess.SY2026

Koopman-BoxQP: Solving Large-Scale NMPC at kHz Rates

Liang Wu, Wallace Gian Yion Tan, Richard D. Braatz +1

Solving large-scale nonlinear model predictive control (NMPC) problems at kilohertz (kHz) rates on standard processors remains a formidable challenge. This paper proposes a Koopman…

cs.SE2026

GlycoPy: A CasADi-based Python Framework for Hierarchical Modeling, Optimization, and Control of Bioprocesses

Yingjie Ma, Jing Guo, Richard D. Braatz

Efficient implementation of nonlinear model predictive control (NMPC) for bioprocesses remains challenging because large nonlinear models are difficult to organize, simulate, and e…

math.OC2025★ 4 cited

Adaptive Nonlinear Model Predictive Control of Monoclonal Antibody Glycosylation in CHO Cell Culture

Yingjie Ma, Jing Guo, Alexis B. Dubs +2

N-glycosylation is a critical quality attribute of monoclonal antibodies (mAbs), the dominant class of biopharmaceuticals. Controlling glycosylation remains difficult due to intrin…

math.OC2025

Bang-Ride Optimal Control: Monotonicity, External Positivity, and Fast Battery Charging

Shengling Shi, Jacob Sass, Jiaen Wu +5

This work studies a class of optimal control problems with scalar inputs and general constraints, whose solutions follow a bang-ride pattern that always activates a constraint and…

math.NA2024★ 6 cited

Quasi-Steady-State Approach for Efficient Multiscale Simulation and Optimization of mAb Glycosylation in CHO Cell Culture

Yingjie Ma, Jing Guo, Andrew Maloney +1

Glycosylation is a critical quality attribute for monoclonal antibody (mAb) production, influenced by both process conditions and cellular mechanisms. Multiscale mechanistic models…