14 citations · 19 across the 26 of their papers we have counts for
28 papers
Integrated Population Balance and Multiphysics Modeling for Predicting Undesired Agglomeration in Small Molecule Manufacturing
Prakitr Srisuma, Peter Hou, Shashank Venkat Muddu +3
Agitated filter dryers (AFDs) are a crucial unit operation in small molecule manufacturing that enables simultaneous filtration, washing, and drying of active pharmaceutical ingred…
Nonadaptive Learning in Robust Nonlinear Output Regulation
Shimin Wang, Martin Guay, Richard D. Braatz
This paper considers robust nonadaptive regulation for general nonlinear systems in an output-feedback setting with arbitrarily high relative degree. We develop a nonadaptive desig…
A Lego Block Approach to Flow in Complex Microfluidic Networks
Etienne Boulais, Richard D. Braatz
We present a new way to construct analytical solutions for flow in complex microfluidic channel networks, as well as planar disordered media. Using a combination of Schwarz-Christo…
Least-Squares Multi-Step Koopman Operator Learning for Model Predictive Control
Liang Wu, Wallace Gian Yion Tan, Leqi Zhou +2
MPC is widely used in real-time applications, but practical implementations are typically restricted to convex QP formulations to ensure fast and certified execution. Koopman-based…
Advanced Characterization Methods for Crystals of an Extraordinary Material
Vivekananda Bal, Jackie M. Wolfrum, Paul W. Barone +4
Physicochemical characterization of materials is central to the field of science and engineering and is essential to design new/engineered materials with specific properties. Assay…
A Time-certified Predictor-corrector IPM Algorithm for Box-QP
Liang Wu, Yunhong Che, Richard D. Braatz +1
Minimizing both the worst-case and average execution times of optimization algorithms is equally critical in real-time optimization-based control applications such as model predict…
Radial Variations in Residence Time Distribution for Pipe Flows
Etienne Boulais, Richard D. Braatz
Suspensions of low-diffusing particles in pipe flows exhibit a difference in age at different radial positions. Particles near the channel walls have higher residence times than th…
Highly Efficient Optimal Control for Lyophilization via Simulation of Discrete/Continuous Mixed-index Differential-algebraic Equations
Prakitr Srisuma, Richard D. Braatz
This article presents a highly efficient optimal control algorithm and policies for lyophilization (also known as freeze drying). The optimal solutions and control policies are der…
A Quadratic Programming Algorithm with Time Complexity
Liang Wu, Richard D. Braatz
Solving linear systems and quadratic programming (QP) problems are both ubiquitous tasks in the engineering and computing fields. Direct methods for solving systems, such as Choles…
Perturbed Gradient Descent Algorithms are Small-Disturbance Input-to-State Stable
Leilei Cui, Zhong-Ping Jiang, Eduardo D. Sontag +1
This article investigates the robustness of gradient descent algorithms under perturbations. The concept of small-disturbance input-to-state stability (ISS) for discrete-time nonli…
Data-Driven Nonlinear Regulation: Gaussian Process Learning
Telema Harry, Martin Guay, Shimin Wang +1
This article addresses the output regulation problem for a class of nonlinear systems using a data-driven approach. An output feedback controller is proposed that integrates a trad…
Arbitrarily Small Execution-Time Certificate: What was Missed in Analog Optimization
Liang Wu, Ambrose Adegbege, Yongduan Song +1
Numerical optimization (solving optimization problems using digital computers) currently dominates but has three major drawbacks: high energy consumption, poor scalability, and lac…
Mechanistic Modeling of Lipid Nanoparticle (LNP) Precipitation via Population Balance Equations (PBEs)
Sunkyu Shin, Cedric Devos, Aniket Pradip Udepurkar +3
Lipid nanoparticles (LNPs) are precisely engineered drug delivery carriers commonly produced through controlled mixing processes, such as nanoprecipitation. Since their delivery ef…
Emergent kinetics of in vitro transcription from interactions of T7 RNA polymerase and DNA
Nathan M. Stover, Marieke De Bock, Julie Chen +4
The in vitro transcription reaction (IVT) is of growing importance for the manufacture of RNA vaccines and therapeutics. While the kinetics of the microscopic steps of this reactio…
Probabilistically Robust Uncertainty Analysis and Optimal Control of Continuous Lyophilization via Polynomial Chaos Theory
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
Lyophilization, aka freeze drying, is a process commonly used to increase the stability of various drug products in biotherapeutics manufacturing, e.g., mRNA vaccines, allowing for…
EIQP: Execution-time-certified and Infeasibility-detecting QP Solver
Liang Wu, Wei Xiao, Richard D. Braatz
Solving real-time quadratic programming (QP) is a ubiquitous task in control engineering, such as in model predictive control and control barrier function-based QP. In such real-ti…
A Phase Diagram for Crystallization of a Complex Macromolecular Assembly
Vivekananda Bal, Jacqueline M. Wolfrum, Paul W. Barone +4
Crystallization of biological molecules has high potential to solve some challenges in drug manufacturing. Thus, understanding the process is critical to efficiently adapting cryst…
An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics
Vivekananda Bal, Moo Sun Hong, Jacqueline M. Wolfrum +5
Crystallization of proteins, specifically proteins of medical relevance, is performed for various reasons such as to understand the protein structure and to design therapies. Obtai…
Selective Enrichment of Full AAV Capsids
Vivekananda Bal, Jacqueline M. Wolfrum, Paul W. Barone +4
Gene therapies using recombinant adeno-associated virus (rAAV) have been developed to treat monogenic and acquired diseases but are currently the most expensive drugs due, in part,…
Simulation-based Approach for Fast Optimal Control of a Stefan Problem with Application to Cell Therapy
Prakitr Srisuma, George Barbastathis, Richard D. Braatz
This article describes a new, efficient way of finding control and state trajectories in optimal control problems by reformulation as a system of differential-algebraic equations (…
Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing
Prakitr Srisuma, Gang Chen, Richard D. Braatz
Lyophilization (aka freeze drying) is a typical process in pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications…
HEK-Omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing
Sai Guna Ranjan Gurazada, Hannah M. Kennedy, Richard D. Braatz +3
Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, this requires robust, scala…
Real-time Estimation of Bound Water Concentration during Lyophilization with Temperature-based State Observers
Prakitr Srisuma, George Barbastathis, Richard Braatz
Lyophilization (aka freeze drying) has been shown to provide long-term stability for many crucial biotherapeutics, e.g., mRNA vaccines for COVID-19, allowing for higher storage tem…
A Parallel Vector-form Decomposition for Accelerating Execution-time-certified -penalty Soft-constrained MPC
Liang Wu, Liwei Zhou, Richard D. Braatz
Handling possible infeasibility and providing an execution time certificate are two pressing requirements of real-time Model Predictive Control (MPC). To meet these two requirement…