43 citations · 72 across the 9 of their papers we have counts for
9 papers
Selective Enrichment of Full AAV Capsids
Vivekananda Bal, Jacqueline M. Wolfrum, Paul W. Barone +4
Gene therapies using recombinant adeno-associated virus (rAAV) have been developed to treat monogenic and acquired diseases but are currently the most expensive drugs due, in part,…
Interpretation of High-Dimensional Regression Coefficients by Comparison with Linearized Compressing Features
Joachim Schaeffer, Jinwook Rhyu, Robin Droop +2
Linear regression is often deemed inherently interpretable; however, challenges arise for high-dimensional data. We focus on further understanding how linear regression approximate…
HEK-Omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing
Sai Guna Ranjan Gurazada, Hannah M. Kennedy, Richard D. Braatz +3
Gene therapy is poised to transition from niche to mainstream medicine, with recombinant adeno-associated virus (rAAV) as the vector of choice. However, this requires robust, scala…
Real-time Estimation of Bound Water Concentration during Lyophilization with Temperature-based State Observers
Prakitr Srisuma, George Barbastathis, Richard Braatz
Lyophilization (aka freeze drying) has been shown to provide long-term stability for many crucial biotherapeutics, e.g., mRNA vaccines for COVID-19, allowing for higher storage tem…
Time-certified Input-constrained NMPC via Koopman Operator
Liang Wu, Krystian Ganko, Richard D. Braatz
Determining solving-time certificates of nonlinear model predictive control (NMPC) implementations is a pressing requirement when deploying NMPC in production environments. Such a…
An Execution-time-certified Riccati-based IPM Algorithm for RTI-based Input-constrained NMPC
Liang Wu, Krystian Ganko, Shimin Wang +1
Establishing an execution time certificate in deploying model predictive control (MPC) is a pressing and challenging requirement. As nonlinear MPC (NMPC) results in nonlinear progr…