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q-bio.QM2026
MetaGEM: Bottom-Up Reconstruction of Genome-Scale Metabolic Networks via Deep Enzyme-Metabolite Anchoring
Weiyu Xiao, Jiangbin Zheng, Stan Z. Li
Genome-scale metabolic models (GEMs) are essential tools for systems biology and rational chassis design, but conventional top-down reconstruction depends heavily on sequence homol…
q-bio.CB2026
TCRTransBench: A Comprehensive Benchmark for Bidirectional TCR-Peptide Sequence Generation
Yiming Wang, Weiyu Xiao, Jiangbin Zheng +1
T-cell receptor (TCR) interactions with antigenic peptides underpin adaptive immunity and are pivotal for personalized immunotherapy and vaccine development. Despite recent progres…