404 citations · 4.7k across the 72 of their papers we have counts for
16 papers · 1 filter
Recent advances in coarse-grained modeling of virus assembly
Michael F. Hagan, Roya Zandi
In many virus families, tens to thousands of proteins assemble spontaneously into a capsid (protein shell) while packaging the genomic nucleic acid. This review summarizes recent a…
The role of packaging sites in efficient and specific virus assembly
J. D. Perlmutter, M. F. Hagan
During the lifecycle of many single-stranded RNA viruses, including many human pathogens, a protein shell called the capsid spontaneously assembles around the viral genome. Underst…
Mechanisms of virus assembly
Jason D Perlmutter, Michael F Hagan
Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell called a capsid, and in some cases surrounded by a lipid bilayer membrane. This review su…
Pathways for virus assembly around nucleic acids
Jason D Perlmutter, Matthew R Perkett, Michael F Hagan
Understanding the pathways by which viral capsid proteins assemble around their genomes could identify key intermediates as potential drug targets. In this work we use computer sim…
Viral genome structures are optimal for capsid assembly
Jason D. Perlmutter, Cong Qiao, Michael F. Hagan
Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applicati…
Modeling Viral Capsid Assembly
Michael F. Hagan
I present a review of the theoretical and computational methodologies that have been used to model the assembly of viral capsids. I discuss the capabilities and limitations of appr…
Diffusion-limited rates on low-dimensional manifolds with extreme aspect ratios
Aleksandr Kivenson, Michael F. Hagan
We consider a single-species diffusion-limited annihilation reaction with reactants confined to a two-dimensional surface with one arbitrarily large dimension and the other compara…
Mechanisms of kinetic trapping in self-assembly and phase transformation
Michael F. Hagan, Oren M. Elrad, Robert L. Jack
In self-assembly processes, kinetic trapping effects often hinder the formation of thermodynamically stable ordered states. In a model of viral capsid assembly and in the phase tra…
Encapsulation of a polymer by an icosahedral virus
Oren M. Elrad, Michael F. Hagan
The coat proteins of many viruses spontaneously form icosahedral capsids around nucleic acids or other polymers. Elucidating the role of the packaged polymer in capsid formation co…
Mechanisms of viral capsid assembly around a polymer
Aleksandr Kivenson, Michael F. Hagan
Capsids of many viruses assemble around nucleic acids or other polymers. Understanding how the properties of the packaged polymer affect the assembly process could promote biomedic…
Prolonging assembly through dissociation:A self assembly paradigm in microtubules
Sumedha, Michael F Hagan, Bulbul Chakraborty
We study a one-dimensional model of microtubule assembly/disassembly in which GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis. In contrast to models th…
Understanding the Concentration Dependence of Viral Capsid Assembly Kinetics - the Origin of the Lag Time and Identifying the Critical Nucleus Size
Michael F. Hagan
The kinetics for the assembly of viral proteins into a population of capsids can be measured in vitro with size exclusion chromatography or dynamic light scattering, but extracting…
A theory for viral capsid assembly around electrostatic cores
Michael F. Hagan
We develop equilibrium and kinetic theories that describe the assembly of viral capsid proteins on a charged central core, as seen in recent experiments in which brome mosaic virus…
Mechanisms of Size Control and Polymorphism in Viral Capsid Assembly
Oren M. Elrad, Michael F. Hagan
We simulate the assembly dynamics of icosahedral capsids from subunits that interconvert between different conformations (or quasi-equivalent states). The simulations identify mech…
Controlling Viral Capsid Assembly with Templating
Michael F. Hagan
We develop coarse-grained models that describe the dynamic encapsidation of functionalized nanoparticles by viral capsid proteins. We find that some forms of cooperative interactio…
Dynamic Pathways for Viral Capsid Assembly
Michael F. Hagan, David Chandler
We develop a class of models with which we simulate the assembly of particles into T1 capsid-like objects using Newtonian dynamics. By simulating assembly for many different values…