404 citations · 4.7k across the 72 of their papers we have counts for
7 papers · 1 filter
The role of the encapsulated cargo in microcompartment assembly
Farzaneh Mohajerani, Michael F. Hagan
Bacterial microcompartments are large, roughly icosahedral shells that assemble around enzymes and reactants involved in certain metabolic pathways in bacteria. Motivated by microc…
Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding
Guillermo R. Lazaro, Suchetana Mukhopadhyay, Michael F. Hagan
During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of…
The Allosteric Switching Mechanism in Bacteriophage MS2
Matthew R. Perkett, Dina T. Mirijanian, Michael F. Hagan
In this article we use all-atom simulations to elucidate the mechanisms underlying conformational switching and allostery within the coat protein of the bacteriophage MS2. Assembly…
Measuring cohesion between macromolecular filaments, one pair at a time: Depletion-induced microtubule bundling
Feodor Hilitski, Andrew R. Ward, Luis Cajamarca +3
In presence of non-adsorbing polymers, colloidal particles experience ubiquitous attractive interactions induced by depletion forces. Here, we measure the depletion interaction bet…
Using Markov State Models to Study Self-Assembly
Matthew R. Perkett, Michael F. Hagan
Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformat…
Simulations of HIV capsid protein dimerization reveal the effect of chemistry and topography on the mechanism of hydrophobic protein association
Naiyin Yu, Michael F. Hagan
Recent work has shown that the hydrophobic protein surfaces in aqueous solution sit near a drying transition. The tendency for these surfaces to expel water from their vicinity lea…
Dynamical Self-regulation in Self-propelled Particle Flows
Arvind Gopinath, Michael F. Hagan, M. Cristina Marchetti +1
We study a continuum model of overdamped self-propelled particles with an aligning interaction in two dimensions. By combining analytical and numerical work, we map out the phase d…