31 citations · 82 across the 6 of their papers we have counts for
6 papers
A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data
Brandon Barker, Narayanan Sadagopan, Yiping Wang +5
A major theme in constraint-based modeling is unifying experimental data, such as biochemical information about the reactions that can occur in a system or the composition and loca…
A three-state kinetic mechanism for scaffold mediated signal transduction
Jason W. Locasale
Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert nu…
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins
Jason W. Locasale, Arup K. Chakraborty
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological…
Signal duration and the time scale dependence of signal integration in biochemical pathways
Jason W. Locasale
Signal duration (e.g. the time scales over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proli…
Computational investigations into the orgins of 'short term' biochemical memory in T cell activation
Jason W. Locasale
Recent studies have reported that T cells can integrate signals between interrupted encounters with Antigen Presenting Cells (APCs) in such a way that the process of signal integra…
Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding
Jason W. Locasale
The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding si…