31 citations · 82 across the 6 of their papers we have counts for
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q-bio.SC2008★ 2 cited
A three-state kinetic mechanism for scaffold mediated signal transduction
Jason W. Locasale
Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert nu…
q-bio.SC2008★ 22 cited
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins
Jason W. Locasale, Arup K. Chakraborty
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological…
q-bio.MN2008★ 1 cited
Signal duration and the time scale dependence of signal integration in biochemical pathways
Jason W. Locasale
Signal duration (e.g. the time scales over which an active signaling intermediate persists) is a key regulator of biological decisions in myriad contexts such as cell growth, proli…