31 citations · 82 across the 6 of their papers we have counts for
Showing q-bio.SCShow all
3 papers · 1 filter
q-bio.SC2008★ 2 cited
A three-state kinetic mechanism for scaffold mediated signal transduction
Jason W. Locasale
Signaling events in eukaryotic cells are often guided by a scaffolding protein. Scaffold proteins assemble multiple proteins in a spatially localized signaling complex and exert nu…
q-bio.SC2008★ 22 cited
Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins
Jason W. Locasale, Arup K. Chakraborty
Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological…
q-bio.SC2007★ 17 cited
Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding
Jason W. Locasale
The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding si…