2 citations · 4 across the 9 of their papers we have counts for
9 papers
Sequence Evolution, Structure and Dynamics of Transmembrane Proteins: Rhodopsin
J. C. Phillips
Rhodopsin is a G-protein coupled receptor found in retinal rod cells, where it mediates monocrhromatic vision in dim light. It is one of the most studied proteins with thousands of…
Evolution of Two Membrane Protein Sequences and Functions
J. C. Phillips
TRPC(3,6) are two ~ 930 amino acid membrane proteins that form calcium permeant cation channels. Here we examine the differences between mammals and oviparous species. Our method i…
Functional Differences of MIP (Lens Fiber Major Intrinsic Protein) Between Animals and Birds
J. C. Phillips
The major intrinsic protein (MIP) of the lens fiber cell membrane plays a role in lens biogenesis and maintenance. Its polypeptide chains span the membrane six times, and the prote…
Biophysical Sequence Analysis of Functional Differences of Piezo1 and Piezo2
J. C. Phillips
Because of their large size and widespread mechanosensitive interactions the only recently discovered titled transmembrane proteins have attracted much attention. Here we present a…
Evolution and Function of SMC Proteins
J. C. Phillips
Structural Maintenance of Chromosomes, SMCs, proteins have long rod like structures immersed in water. Here we use our hydroanalytic methods based on amino acid sequences to discus…
From Omicron to Its BA.5 Subvariant: A New Twist in Coronavirus Contagiousness Evolution
J. C. Phillips
In 2022 new subvariants of Coronavirus appeared in South Africa, and spread rapidly to other parts of the world. The effects of selective evolution on increasing the already high c…
Evolution and Mutations of Beta 2 Microglobulin
J. C. Phillips
Here we examine the evolution of beta-2 microglobulin in terms of its hydropathic shapes, a theoretical construct that has revealed important trends. The dynamics of many proteins…
Evolution of Transthyretin
J. C. Phillips
Evolution of the amino acid sequences of transthyretin (TTR) can provide additional information about its dynamics that both complements and extends the already extensive static st…
Why and How Coronavirus Has Evolved to Be Uniquely Contagious, with Uniquely Successful Stable Vaccines
Marcelo A. Moret, Gilney F. Zebende, J. C. Phillips
Spike proteins, 1200 amino acids, are divided into two nearly equal parts, S1 and S2. We review here phase transition theory, implemented quantitatively by thermodynamic scaling. T…