2 citations · 3 across the 4 of their papers we have counts for
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Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1
Colin LaMont, Jakub Otwinowski, Kanika Vanshylla +3
Broadly neutralizing antibodies (bNAbs) are promising targets for vaccination and therapy against HIV. Passive infusions of bNAbs have shown promise in clinical trials as a potenti…
Information-geometric optimization with natural selection
Jakub Otwinowski, Colin LaMont
Evolutionary algorithms, inspired by natural evolution, aim to optimize difficult objective functions without computing derivatives. Here we detail the relationship between populat…
Fierce selection and interference in B-cell repertoire response to chronic HIV-1
Armita Nourmohammad, Jakub Otwinowski, Marta Łuksza +2
During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host's adaptive immune system. While it is clear that HIV exerts strong selection on the adapti…