1 citations · 1 across the 1 of their papers we have counts for
3 papers
Learning the shape of protein micro-environments with a holographic convolutional neural network
Michael N. Pun, Andrew Ivanov, Quinn Bellamy +5
Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure f…
Dynamics of B-cell repertoires and emergence of cross-reactive responses in COVID-19 patients with different disease severity
Zachary Montague, Huibin Lv, Jakub Otwinowski +12
COVID-19 patients show varying severity of the disease ranging from asymptomatic to requiring intensive care. Although a number of SARS-CoV-2 specific monoclonal antibodies have be…
Fierce selection and interference in B-cell repertoire response to chronic HIV-1
Armita Nourmohammad, Jakub Otwinowski, Marta Łuksza +2
During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host's adaptive immune system. While it is clear that HIV exerts strong selection on the adapti…