29 citations · 45 across the 4 of their papers we have counts for
4 papers
Contrastive losses as generalized models of global epistasis
David H. Brookes, Jakub Otwinowski, Sam Sinai
Fitness functions map large combinatorial spaces of biological sequences to properties of interest. Inferring these multimodal functions from experimental data is a central task in…
Clonal interference and Muller's ratchet in spatial habitats
Jakub Otwinowski, Joachim Krug
Competition between independently arising beneficial mutations is enhanced in spatial populations due to the linear rather than exponential growth of clones. Recent theoretical stu…
Accumulation of beneficial mutations in one dimension
Jakub Otwinowski, Stefan Boettcher
When beneficial mutations are relatively common, competition between multiple unfixed mutations can reduce the rate of fixation in well-mixed asexual populations. We introduce a on…
Totally Asymmetric Exclusion Process with Hierarchical Long-Range Connections
Jakub Otwinowski, Stefan Boettcher
A non-equilibrium particle transport model, the totally asymmetric exclusion process, is studied on a one-dimensional lattice with a hierarchy of fixed long-range connections. This…