5 papers · 1 filter
Neutralization titers reveal the structure of polyclonal antibody responses
Henry Alston, Thierry Mora, Aleksandra M. Walczak
The composition of a polyclonal antibody response is hard to measure experimentally but contains vital information about the robustness of immunity. Here, we argue that the statist…
Modeling Protein Evolution via Generative Inference From Monte Carlo Chains to Population Genetics
Leonardo Di Bari, Thierry Mora, Andrea Pagnani +3
Generative models derived from large protein sequence alignments define complex fitness landscapes, but their utility for accurately modeling non-equilibrium evolutionary dynamics…
Dynamics of memory B cells and plasmablasts in healthy individuals
Andrea Mazzolini, Aleksandra M. Walczak, Thierry Mora
Our adaptive immune system relies on the persistence over long times of a diverse set of antigen-experienced B cells to encode our memories of past infections and to protect us aga…
How host mobility patterns shape antigenic escape during viral-immune co-evolution
Natalie Blot, Caelan Brooks, Daniel W. Swartz +6
Viruses like influenza have long coevolved with host immune systems, gradually shaping the evolutionary trajectory of these pathogens. Host immune systems develop immunity against…
Computational detection of antigen specific B cell receptors following immunization
Maria Francesca Abbate, Thomas Dupic, Emmanuelle Vigne +3
B cell receptors (BCRs) play a crucial role in recognizing and fighting foreign antigens. High-throughput sequencing enables in-depth sampling of the BCRs repertoire after immuniza…