204 citations · 249 across the 11 of their papers we have counts for
11 papers
Invention, Innovation, and Commercialisation in British Biophysics
Jack Shepherd, Mark Leake
British biophysics has a tradition of scientific invention and innovation, resulting in new technologies transforming biological insight, such as rapid DNA sequencing, super-resolu…
Correlating fluorescence microscopy, optical and magnetic tweezers to study single chiral biopolymers such as DNA
Jack W Shepherd, Sebastien Guilbaud, Zhaokun Zhou +7
Biopolymer topology is critical for determining interactions inside cell environments, exemplified by DNA where its response to mechanical perturbation is as important as biochemic…
RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in live Escherichia coli with single-molecule sensitivity
Alex L. Payne-Dwyer, Aisha H. Syeda, Jack W. Shepherd +2
The RecA protein and RecBCD complex are key bacterial components for the maintenance and repair of DNA, RecBCD a helicase-nuclease that uses homologous recombination to resolve dou…
The End Restraint Method for Mechanically Perturbing Nucleic Acids in silico
Jack W Shepherd, Mark C Leake
Far from being a passive information store, the genome is a mechanically dynamic and diverse system in which torsion and tension fluctuate and combine to determine structure and he…
Investigating molecular crowding during cell division in budding yeast with FRET
Sarah Lecinski, Jack W Shepherd, Lewis Frame +3
Cell division, aging, and stress recovery triggers spatial reorganization of cellular components in the cytoplasm, including membrane bound organelles, with molecular changes in th…
PySTACHIO: Python Single-molecule TrAcking stoiCHiometry Intensity and simulatiOn, a flexible, extensible, beginner-friendly and optimized program for analysis of single-molecule microscopy
Jack W Shepherd, Ed J Higgins, Adam J M Wollman +1
As camera pixel arrays have grown larger and faster, and optical microscopy techniques ever more refined, there has been an explosion in the quantity of data acquired during routin…