204 citations · 249 across the 11 of their papers we have counts for
4 papers · 1 filter
RecA and RecB: probing complexes of DNA repair proteins with mitomycin C in live Escherichia coli with single-molecule sensitivity
Alex L. Payne-Dwyer, Aisha H. Syeda, Jack W. Shepherd +2
The RecA protein and RecBCD complex are key bacterial components for the maintenance and repair of DNA, RecBCD a helicase-nuclease that uses homologous recombination to resolve dou…
The End Restraint Method for Mechanically Perturbing Nucleic Acids in silico
Jack W Shepherd, Mark C Leake
Far from being a passive information store, the genome is a mechanically dynamic and diverse system in which torsion and tension fluctuate and combine to determine structure and he…
PySTACHIO: Python Single-molecule TrAcking stoiCHiometry Intensity and simulatiOn, a flexible, extensible, beginner-friendly and optimized program for analysis of single-molecule microscopy
Jack W Shepherd, Ed J Higgins, Adam J M Wollman +1
As camera pixel arrays have grown larger and faster, and optical microscopy techniques ever more refined, there has been an explosion in the quantity of data acquired during routin…
The emergence of sequence-dependent structural motifs in stretched, torsionally constrained DNA
Jack W Shepherd, Robert J Greenall, Matt I J Probert +2
The double-helical structure of DNA results from canonical base pairing and stacking interactions. However, variations from steady-state conformations result from mechanical pertur…