4 papers · 1 filter
Analyzing \b{eta}-Lactamase Evolution from the Principle of Least Action Perspective
Pablo Garay, Walter J. Lapadula, Maximiliano Juri Ayub +1
Protein sequences change over time due to the accumulation of mutations in the genes that encode them. Nonetheless, accurately identifying the most probable evolutionary pathways a…
Factors controlling protein evolvability, at the molecular scale
Jorge A. Vila
This piece serves two purposes. Firstly, it aims at elucidating the role of epistasis in shaping, at a molecular level, the evolutionary paths of proteins, as well as the extent to…
Physical principles underpinning molecular-level protein evolution
J. A. Vila
Since protein mutations are the main driving force of evolution at the molecular level, a proper analysis of them (and the factors controlling them) will enable us to find a respon…
The Origin of Mutational Epistasis
Jorge A. Vila
The interconnected processes of protein folding, mutations, epistasis, and evolution have all been the subject of extensive analysis throughout the years due to their significance…