7 papers
Analyzing \b{eta}-Lactamase Evolution from the Principle of Least Action Perspective
Pablo Garay, Walter J. Lapadula, Maximiliano Juri Ayub +1
Protein sequences change over time due to the accumulation of mutations in the genes that encode them. Nonetheless, accurately identifying the most probable evolutionary pathways a…
Decoding How Proteins Fold
Jorge Vila
One of the most puzzling and unsolved challenges in molecular biology is understanding how proteins fold. Despite having advanced predictive tools that can accurately estimate the…
Factors controlling protein evolvability, at the molecular scale
Jorge A. Vila
This piece serves two purposes. Firstly, it aims at elucidating the role of epistasis in shaping, at a molecular level, the evolutionary paths of proteins, as well as the extent to…
Physical principles underpinning molecular-level protein evolution
J. A. Vila
Since protein mutations are the main driving force of evolution at the molecular level, a proper analysis of them (and the factors controlling them) will enable us to find a respon…
The Origin of Mutational Epistasis
Jorge A. Vila
The interconnected processes of protein folding, mutations, epistasis, and evolution have all been the subject of extensive analysis throughout the years due to their significance…
Analysis of proteins in the light of mutations
Jorge A. Vila
Proteins have evolved through mutations, amino acid substitutions, since life appeared on Earth, some 109 years ago. The study of these phenomena has been of particular significanc…
The Marginal Stability of Proteins: How Jiggling and Wiggling of Atoms are Connected to Neutral Evolution
Osvaldo A. Martin, Jorge A. Vila
Here we propose that the upper bound marginal stability of proteins (7.4 kcal/mol) is a universal property that includes macro-molecular complexes and is not affected by molecular…