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q-bio.BM2026
Decoding How Proteins Fold
Jorge Vila
One of the most puzzling and unsolved challenges in molecular biology is understanding how proteins fold. Despite having advanced predictive tools that can accurately estimate the…
q-bio.BM2023
Analysis of proteins in the light of mutations
Jorge A. Vila
Proteins have evolved through mutations, amino acid substitutions, since life appeared on Earth, some 109 years ago. The study of these phenomena has been of particular significanc…
q-bio.BM2019
The Marginal Stability of Proteins: How Jiggling and Wiggling of Atoms are Connected to Neutral Evolution
Osvaldo A. Martin, Jorge A. Vila
Here we propose that the upper bound marginal stability of proteins (7.4 kcal/mol) is a universal property that includes macro-molecular complexes and is not affected by molecular…