51 citations · 211 across the 9 of their papers we have counts for
4 papers · 1 filter
Analysis of Inducer and Operator Binding for Cyclic-AMP Receptor Protein Mutants
Tal Einav, Julia Duque, Rob Phillips
Allosteric transcription factors undergo binding events both at their inducer binding sites as well as at distinct DNA binding domains, and it is often difficult to disentangle the…
Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction
Manuel Razo-Mejia, Stephanie L. Barnes, Nathan M. Belliveau +4
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its…
Monod-Wyman-Changeux Analysis of Ligand-Gated Ion Channel Mutants
Tal Einav, Rob Phillips
We present a framework for computing the gating properties of ligand-gated ion channel mutants using the Monod-Wyman-Changeux (MWC) model of allostery. We derive simple analytic fo…
Statistical Mechanics of Allosteric Enzymes
Tal Einav, Linas Mazutis, Rob Phillips
The concept of allostery in which macromolecules switch between two different conformations is a central theme in biological processes ranging from gene regulation to cell signalin…