4 papers
New algorithm to determine a minimal representation of the molecular surface
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +3
Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especiall…
Competing endogenous RNA crosstalk at system level
Mattia Miotto, Enzo Marinari, Andrea De Martino
microRNAs (miRNAs) regulate gene expression at post-transcriptional level by repressing target RNA molecules. Competition to bind miRNAs tends in turn to correlate their targets, e…
Exploration-exploitation tradeoffs dictate the optimal distributions of phenotypes for populations subject to fitness fluctuations
Andrea De Martino, Thomas Gueudré, Mattia Miotto
We study a minimal model for the growth of a phenotypically heterogeneous population of cells subject to a fluctuating environment in which they can replicate (by exploiting availa…
Entropy evaluation sheds light on ecosystem complexity
Mattia Miotto, Lorenzo Monacelli
Preserving biodiversity and ecosystem stability is a challenge that can be pursued through modern statistical mechanics modeling. Here we introduce a variational maximum entropy-ba…