101 citations · 474 across the 28 of their papers we have counts for
7 papers · 1 filter
Deciphering the chemical grammar of protein-RNA condensates
Greta Grassmann, Giancarlo Ruocco, Mattia Miotto
Biomolecular phase separation is typically attributed to the polymer physics of long, disordered chains. However, the underlying chemical grammar, i.e. the specific interactions be…
High throughput interactome determination via sulfur anomalous scattering
Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci +2
We propose a novel approach to detect the binding between proteins making use of the anomalous diffraction of natively present heavy elements inside the molecule 3D structure. In p…
A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +7
Many of the molecular mechanisms underlying the pathological aggregation of proteins observed in neurodegenerative diseases are still not fully understood. Among the diseases assoc…
Investigating the side-chain structural organization behind the stability of protein folding and binding
Fausta Desantis, Mattia Miotto, Lorenzo Di Rienzo +2
What are the molecular mechanisms that dictate protein-protein binding stability and whether those are related to the ones behind protein fold stability are still largely open ques…
New algorithm to determine a minimal representation of the molecular surface
Greta Grassmann, Mattia Miotto, Lorenzo Di Rienzo +3
Most proteins perform their biological function by interacting with one or more molecular partners. In this respect, characterizing the features of the molecular surface, especiall…
In-Silico evidence for two receptors based strategy of SARS-CoV-2
Edoardo Milanetti, Mattia Miotto, Lorenzo Di Rienzo +3
We propose a novel numerical method able to determine efficiently and effectively the relationship of complementarity between portions of proteins surfaces. This innovative and gen…
Entropy evaluation sheds light on ecosystem complexity
Mattia Miotto, Lorenzo Monacelli
Preserving biodiversity and ecosystem stability is a challenge that can be pursued through modern statistical mechanics modeling. Here we introduce a variational maximum entropy-ba…