31 citations · 64 across the 16 of their papers we have counts for
3 papers · 1 filter
Multi-indication evidence synthesis in oncology health technology assessment
Janharpreet Singh, Sumayya Anwer, Stephen Palmer +5
Background: Cancer drugs receive licensing extensions to include additional indications as trial evidence on treatment effectiveness accumulates. We investigate how sharing informa…
Individual participant data from digital sources informed and improved precision in the evaluation of predictive biomarkers in Bayesian network meta-analysis
Chinyereugo M Umemneku-Chikere, Lorna Wheaton, Heather Poad +7
Objective: We aimed to develop a meta-analytic model for evaluation of predictive biomarkers and targeted therapies, utilising data from digital sources when individual participant…
Bayesian meta-analysis for evaluating treatment effectiveness in biomarker subgroups using trials of mixed patient populations
Lorna Wheaton, Dan Jackson, Sylwia Bujkiewicz
During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed popula…