79 citations · 138 across the 10 of their papers we have counts for
10 papers
The Site Frequency Spectrum in an Exponentially Growing Population with Selection
Armaan Ahmed, Jasmine Foo, Einar Gunnarsson +1
We consider a supercritical two-type continuous-time linear birth-death process with mutation and selection, in which wild-type individuals give rise to mutant offspring with a lar…
Optimal dosing of anti-cancer treatment under drug-induced plasticity
Einar Bjarki Gunnarsson, Benedikt Vilji Magnússon, Jasmine Foo
While cancer has traditionally been considered a genetic disease, mounting evidence indicates an important role for non-genetic (epigenetic) mechanisms. Common anti-cancer drugs ha…
A statistical framework for detecting therapy-induced resistance from drug screens
Chenyu Wu, Einar Bjarki Gunnarsson, Jasmine Foo +1
Resistance to therapy remains a significant challenge in cancer treatment, often due to the presence of a stem-like cell population that drives tumor recurrence post-treatment. Mor…
Limit theorems for the site frequency spectrum of neutral mutations in an exponentially growing population
Einar Bjarki Gunnarsson, Kevin Leder, Xuanming Zhang
The site frequency spectrum (SFS) is a widely used summary statistic of genomic data. Motivated by recent evidence for the role of neutral evolution in cancer, we investigate the S…
Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
Einar Bjarki Gunnarsson, Jasmine Foo, Kevin Leder
Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer evolution. In many cancers, these mechanisms have been observed to i…
Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data
C. Wu, E. B. Gunnarsson, E. M. Myklebust +6
Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety…
Dynamics of advantageous mutant spread in spatial death-birth and birth-death Moran models
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
The spread of an advantageous mutation through a population is of fundamental interest in population genetics. While the classical Moran model is formulated for a well-mixed popula…
Exact site frequency spectra of neutrally evolving tumors: a transition between power laws reveals a signature of cell viability
Einar Bjarki Gunnarsson, Kevin Leder, Jasmine Foo
The site frequency spectrum (SFS) is a popular summary statistic of genomic data. While the SFS of a constant-sized population undergoing neutral mutations has been extensively stu…
Spread of premalignant mutant clones and cancer initiation in multilayered tissue
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
Over 80% of human cancers originate from the epithelium, which covers the outer and inner surfaces of organs and blood vessels. In stratified epithelium, the bottom layers are occu…
Understanding the role of phenotypic switching in cancer drug resistance
Einar Bjarki Gunnarsson, Subhajyoti De, Kevin Leder +1
The emergence of acquired drug resistance in cancer represents a major barrier to treatment success. While research has traditionally focused on genetic sources of resistance, rece…