79 citations · 138 across the 10 of their papers we have counts for
3 papers · 1 filter
Limit theorems for the site frequency spectrum of neutral mutations in an exponentially growing population
Einar Bjarki Gunnarsson, Kevin Leder, Xuanming Zhang
The site frequency spectrum (SFS) is a widely used summary statistic of genomic data. Motivated by recent evidence for the role of neutral evolution in cancer, we investigate the S…
Statistical inference of the rates of cell proliferation and phenotypic switching in cancer
Einar Bjarki Gunnarsson, Jasmine Foo, Kevin Leder
Recent evidence suggests that nongenetic (epigenetic) mechanisms play an important role at all stages of cancer evolution. In many cancers, these mechanisms have been observed to i…
Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data
C. Wu, E. B. Gunnarsson, E. M. Myklebust +6
Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety…