79 citations · 138 across the 10 of their papers we have counts for
3 papers · 1 filter
The Site Frequency Spectrum in an Exponentially Growing Population with Selection
Armaan Ahmed, Jasmine Foo, Einar Gunnarsson +1
We consider a supercritical two-type continuous-time linear birth-death process with mutation and selection, in which wild-type individuals give rise to mutant offspring with a lar…
Limit theorems for the site frequency spectrum of neutral mutations in an exponentially growing population
Einar Bjarki Gunnarsson, Kevin Leder, Xuanming Zhang
The site frequency spectrum (SFS) is a widely used summary statistic of genomic data. Motivated by recent evidence for the role of neutral evolution in cancer, we investigate the S…
Spread of premalignant mutant clones and cancer initiation in multilayered tissue
Jasmine Foo, Einar Bjarki Gunnarsson, Kevin Leder +1
Over 80% of human cancers originate from the epithelium, which covers the outer and inner surfaces of organs and blood vessels. In stratified epithelium, the bottom layers are occu…