161 citations · 347 across the 9 of their papers we have counts for
9 papers
Resolving the Orientations of and Angular Separation between a Pair of Dipole Emitters
Yiyang Chen, Yuanxin Qiu, Matthew D. Lew
We prove that it is impossible to distinguish two spatially coinciding fluorescent molecules from a single rotating molecule using polarization-sensitive imaging, even if one modul…
Dipole-Spread Function Engineering for 6D Super-Resolution Microscopy
Tingting Wu, Matthew D. Lew
Fluorescent molecules are versatile nanoscale emitters that enable detailed observations of biophysical processes with nanoscale resolution. Because they are well-approximated as e…
Towards optimal point spread function design for resolving closely spaced emitters in three dimensions
James M. Jusuf, Matthew D. Lew
The past decade has brought many innovations in optical design for 3D super-resolution imaging of point-like emitters, but these methods often focus on single-emitter localization…
Single-molecule orientation localization microscopy II: a performance comparison
Oumeng Zhang, Matthew D. Lew
Various techniques have been developed to measure the 2D and 3D positions and 2D and 3D orientations of fluorescent molecules with improved precision over standard epifluorescence…
Single-molecule orientation localization microscopy I: fundamental limits
Oumeng Zhang, Matthew D. Lew
Precisely measuring the three-dimensional position and orientation of individual fluorophores is challenging due to the substantial photon shot noise in single-molecule experiments…
Quantum limits for precisely estimating the orientation and wobble of dipole emitters
Oumeng Zhang, Matthew D. Lew
Precisely measuring molecular orientation is key to understanding how molecules organize and interact in soft matter, but the maximum theoretical limit of measurement precision has…
Dense Super-Resolution Imaging of Molecular Orientation via Joint Sparse Basis Deconvolution and Spatial Pooling
Hesam Mazidi, Eshan S. King, Oumeng Zhang +2
In single-molecule super-resolution microscopy, engineered point-spread functions (PSFs) are designed to efficiently encode new molecular properties, such as 3D orientation, into c…
Fundamental Limits on Measuring the Rotational Constraint of Single Molecules using Fluorescence Microscopy
Oumeng Zhang, Matthew D. Lew
Optical fluorescence imaging is capable of measuring both the spatial and rotational dynamics of single molecules. However, unavoidable measurement noise will result in inaccurate…
Speckle-Free Coherence Tomography of Turbid Media
Orly Liba, Matthew D. Lew, Elliott D. SoRelle +5
Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a…