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q-bio.MN2016
Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression
Ding Ma, Laurence Yang, Ronan M. T. Fleming +3
Constraint-Based Reconstruction and Analysis (COBRA) is currently the only methodology that permits integrated modeling of Metabolism and macromolecular Expression (ME) at genome-s…
q-bio.MN2011
A variational principle for computing nonequilibrium fluxes and potentials in genome-scale biochemical networks
Ronan M. T. Fleming, Christopher M. Maes, Michael A. Saunders +2
We derive a convex optimization problem on a steady-state nonequilibrium network of biochemical reactions, with the property that energy conservation and the second law of thermody…