2 papers
math.OC2020
Scalable computation of intracellular metabolite concentrations
Amir Akbari, Bernhard O. Palsson
Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direc…
q-bio.QM2018
Estimating Cellular Goals from High-Dimensional Biological Data
Laurence Yang, Michael A. Saunders, Jean-Christophe Lachance +2
Optimization-based models have been used to predict cellular behavior for over 25 years. The constraints in these models are derived from genome annotations, measured macro-molecul…