Collective effects in intra-cellular molecular motor transport: coordination, cooperation and competetion
arXiv:physics/0605053 · doi:10.1016/j.physa.2006.05.005
Abstract
Molecular motors do not work in isolation {\it in-vivo}. We highlight some of the coordinations, cooperations and competitions that determine the collective properties of molecular motors in eukaryotic cells. In the context of traffic-like movement of motors on a track, we emphasize the importance of single-motor bio-chemical cycle and enzymatic activity on their collective spatio-temporal organisation. Our modelling strategy is based on a synthesis- the same model describes the single-motor mechano-chemistry at sufficiently low densities whereas at higher densities it accounts for the collective flow properties and the density profiles of the motors. We consider two specific examples, namely, traffic of single-headed kinesin motors KIF1A on a microtubule track and ribosome traffic on a messenger RNA track.
9 pages including LATEX text and 9 EPS figures
References in corpus (19)
- Brownian motors: noisy transport far from equilibrium
- Statistical Physics of Vehicular Traffic and Some Related Systems
- Phase Coexistence in Driven One Dimensional Transport
- Cooperative Cargo Transport by Several Molecular Motors
- The totally asymmetric exclusion process with extended objects, a model for protein synthesis
- Physics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms
- Clustered bottlenecks in mRNA translation and protein synthesis
- The Totally Asymmetric Simple Exclusion Process with Langmuir Kinetics
- Intra-cellular transport of single-headed molecular motors KIF1A
- Shock formation in an exclusion process with creation and annihilation
- Localization of shocks in driven diffusive systems without particle number conservation
- Local Inhomogeneity in Asymmetric Simple Exclusion Processes with Extended Objects
- A Simple Kinetic Model Describes the Processivity of Myosin-V
- Ribosome recycling, diffusion, and mRNA loop formation in translational regulation
- Understanding Mechanochemical Coupling in Kinesins Using First-Passage Time Processes
- Mean field approaches to the totally asymmetric exclusion process with quenched disorder and large particles
- Dynamics of an exclusion process with creation and annihilation
- Oscillations in molecular motor assemblies
- Sequence heterogeneity and the dynamics of molecular motors