Unzipping of DNA with correlated base-sequence

Abstract

We consider force-induced unzipping transition for a heterogeneous DNA model with a correlated base-sequence. Both finite-range and long-range correlated situations are considered. It is shown that finite-range correlations increase stability of DNA with respect to the external unzipping force. Due to long-range correlations the number of unzipped base-pairs displays two widely different scenarios depending on the details of the base-sequence: either there is no unzipping phase-transition at all, or the transition is realized via a sequence of jumps with magnitude comparable to the size of the system. Both scenarios are different from the behavior of the average number of unzipped base-pairs (non-self-averaging). The results can be relevant for explaining the biological purpose of correlated structures in DNA.

22 pages, revtex4, 14 eps figures; reprinted in the June 15, 2004 issue of Virtual Journal of Biological Physics Research

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• Thermodynamic relations for DNA phase transitions
• On quenched and annealed critical curves of random pinning model with finite range correlations
• Interfacial instability and DNA fork reversal by repair proteins
• Force Induced Unzipping of DNA with Long Range Correlated Noise
• Forest-Fire Model with Resistant Trees
• Two Pinning Models with Markov disorder