DNA sequence from the unzipping force? : one mutation problem

Abstract

The possibility of detecting mutations in a DNA from force measurements (as a first step towards sequence analysis) is discussed theoretically based on exact calculations. The force signal is associated with the domain wall separating the zipped from the unzipped regions. We propose a comparison method (``differential force microscope'') to detect mutations. Two lattice models are treated as specific examples.

11 pages, 4 figures. Revised version with minor changes. Paragraph with discussion on experiments added. Accepted for publication in J. Phys. A as a Letter to the Editor

References in corpus (4)

• Single Molecule Statistics and the Polynucleotide Unzipping Transition
• Dynamical scaling of the DNA unzipping transition
• Phase diagram of force-induced DNA unzipping in exactly solvable models
• Force-induced denaturation of RNA

Cited by in corpus (11)

• Single-molecule experiments in biological physics: methods and applications
• Complete Phase Diagram of DNA Unzipping: Eye, Y-fork and triple point
• Statistical Theory of Force Induced Unzipping of DNA
• Inferring DNA sequences from mechanical unzipping data: the large-bandwidth case
• Unzipping of DNA with correlated base-sequence
• Helicase activity on DNA as a propagating front
• Helicase on DNA: A Phase coexistence based mechanism
• Can a double stranded DNA be unzipped by pulling a single strand?: Phases of adsorbed DNA
• Elasticity of a DNA chain dotted with bubbles under force
• Unzipping of two random heteropolymers: Ground state energy and finite size effects
• A model for the force stretching double-stranded chain molecules