Interferometric Mass Photometry at the Quantum Limit of Sensitivity

Abstract

We present an innovative optical imaging system for measuring parameters of a small particle such as a macromolecule or nanoparticle at the quantum limit of sensitivity. In comparison to the conventional confocal interferometric scattering (iSCAT) approach, our setup adds a second arm to form a Michelson interferometer that allows us to tune a relative phase. We evaluate the quantum Cramér-Rao bound (QCRB) for different quantum states, including single-mode coherent states, multi-frequency coherent states, and phase-averaged coherent states. Our results show that the proposed setup can achieve the QCRB of sensitivity and outperform iSCAT for all considered quantum states for mass and phase estimation of a particle.

References in corpus (8)

• The point spread function in interferometric scattering microscopy (iSCAT). I. Aberrations in defocusing and axial localization
• Maximum information states for coherent scattering measurements
• Fundamental bounds on the precision of iSCAT, COBRI and dark-field microscopy for 3D localization and mass photometry
• Fundamental bounds on the precision of classical phase microscopes
• Multiscale Modeling and Analysis for High-fidelity Interferometric Scattering Microscopy
• Quantum theory of Rayleigh scattering
• Super-Resolution Imaging with Multiparameter Quantum Metrology in Passive Remote Sensing
• Direct phase mapping of the light scattered by single plasmonic nanoparticles