Noise-induced acceleration of single molecule kinesin-1

Abstract

The movement of single kinesin molecules was observed while applying noisy external forces that mimic intracellular active fluctuations. We found kinesin accelerates under noise, especially when a large hindering load is added. The behavior quantitatively conformed to a theoretical model that describes the kinesin movement with simple two-state reactions. The universality of the kinetic theory suggests that intracellular enzymes share a similar noise-induced acceleration mechanism, i.e. active fluctuations in cells are not just noise but are utilized to promote various physiological processes.

arXiv comment6 pages for the main text and 18 pages for the Supplemental Material

References in corpus (4)

• Equality connecting energy dissipation with violation of fluctuation-response relation
• Activity driven fluctuations in living cells
• Loopy Lévy flights enhance tracer diffusion in active suspensions
• Kinesin's backsteps under mechanical load

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• Harvesting information to control non-equilibrium states of active matter
• Estimate of entropy generation rate can spatiotemporally resolve the active nature of cell flickering
• Violation of the second fluctuation-dissipation relation and entropy production in nonequilibrium medium