Estimate of entropy generation rate can spatiotemporally resolve the active nature of cell flickering
arXiv:2205.12849 · doi:10.1103/PhysRevResearch.6.023310
Abstract
We use the short-time inference scheme (Manikandan, Gupta and Krishnamurthy, Phys. Rev. Lett. 124, 120603, 2020), obtained within the framework of stochastic thermodynamics, to infer a lower-bound to entropy generation rate from flickering data generated by Interference Reflection Microscopy of HeLA cells. We can clearly distinguish active cell membranes from their ATP depleted selves and even spatio-temporally resolve activity down to the scale of about one m. Our estimate of activity is model--independent.
Published version
References in corpus (13)
- Thermodynamic uncertainty relation for biomolecular processes
- Biological and synthetic membranes: What can be learned from a coarse-grained description?
- Improved bounds on entropy production in living systems
- Experimental Realization of a Minimal Microscopic Heat Engine
- Hierarchical Bounds on Entropy Production Inferred from Partial Information
- Variance Sum Rule for Entropy Production
- Work fluctuations for a Brownian particle in a harmonic trap with fluctuating locations
- Noise-induced acceleration of single molecule kinesin-1
- How irreversible are steady-state trajectories of a trapped active particle?
- Stress reorganisation and response in active solids
- Quantitative analysis of non-equilibrium systems from short-time experimental data
- Irreversibility in active matter: General framework for active Ornstein-Uhlenbeck particles
- A sensitive calorimetric technique to study energy (heat) exchange at the nano-scale